Conrad lost a lot of his life to Pillars of Eternity when he reviewed it. Clearly the poor sap was playing it wrong because Jiseed beat the damn thing in less time than it takes to watch the newest watercooler TV episode.
Skill, some sequence breaking, and major glitches (Obsidian!) all help out with this speedrun. The glitch where you kill off your main character during transitions and are gifted with a prebuilt level 7 Cypher that knows two debug spells seems to have helped immensely. You can find more detail here.